The Northwestern University Transgenic and Targeted Mutagenesis Laboratory (TTML) is a shared resource designed to produce genetically engineered mice for research projects of investigators on the Evanston campus, in the Feinberg School of Medicine, the Robert H. Lurie Comprehensive Cancer Center, and the Children's Hospital of Chicago Research Center.
Our laboratory provides a broad, comprehensive range of services to NU investigators, including generation of transgenic mice, gene targeting of embryonic stem (ES) cells, ES cell microinjection into blastocysts to create germline competent chimera, cryopreservation and long-term storage of mouse sperm/embryos, recovery of mouse lines from cryopreserved germplasm, in vitro fertilization (for mouse line rescue), and rederivation of pathogen free mouse strains.
- About Us
Connect with us and learn more about our services
- Transgenic and Targeted Mutagenesis Mouse Strains
Learn about our available mouse strains
Get answers to common questions about our core
Access external mouse databases
- Transgenics Projects
Learn about the TTML process for producing transgenic mice
- Gene Targeting
Get details about our work in gene targeting with chimeric mice
- ES Cell Injection
Understand our process for culturing and/or injecting ES cells for investigators
Find details and pricing related to the TTML's rederivation process
- Cryopreservation of Mouse Lines
Learn more about our offerings in this critical service related to modern mouse based genomics
- Cryorecovery of Mouse Lines
Discover the processes and costs related to our cryorecovery services
Our Track Record / What's New
Since 2008, the laboratory has completed fifty gene targeting projects with a success rate of 98%.
Find out more about our track record and what's new at TTML.
TTML is sponsored by
The Center for Genetic Medicine
The Robert H. Lurie Comprehensive Cancer Center
Feinberg School of Medicine, Office of the Dean
Office of the Vice President for Research