Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Animal Models of Human Disease

Allada, Ravi

Allada, Ravi

Professor of Weinberg College of Arts and Sciences and Pathology

Andersen, Erik

Andersen, Erik

Assistant Professor, Department of Molecular Biosciences Weinberg College of Arts and Sciences, Northwestern University

erik.andersen( at )northwestern.edu

Description of Interests

Classical, quantitative, and molecular genetics of complex traits

Bartles, James R

Bartles, James R

Professor of Cell and Molecular Biology

j-bartles( at )northwestern.edu

Description of Interests

The research in my lab is centered on the "espins," a family of multifunctional actin-bundling proteins, and the elucidation of their roles in the organization and function of hair cell stereocilia. E... [more]

Bass, Joseph T

Bass, Joseph T

Professor of Medicine (Endocrinology)

j-bass( at )northwestern.edu

Baumann, Gerhard

Baumann, Gerhard

Professor Emeritus of Medicine (Endocrinology)

Description of Interests

growth hormone, growth hormone action, growth hormone receptor, growth hormone binding protein, growth hormone releasing hormone receptor, insulin-like growth factor, growth, development, metabolism

Beitel, Gregory J

Beitel, Gregory J

Professor of Weinberg College of Arts and Sciences and Medicine (Pulmonary and Critical Care)

Berdnikovs, Sergejs

Berdnikovs, Sergejs

Research Assistant Professor of Medicine (Allergy and Immunology)

Description of Interests

The question of primary interest in my lab is why only select individuals, despite being genetically similar and living in the same allergen environment, are prone to developing allergic disease, and ... [more]

Brannigan, Robert E

Brannigan, Robert E

Professor of Urology

Description of Interests

Dr. Robert E. Brannigan's clinical concentration is male reproductive medicine and surgery. His surgical interests included performing: microsurgical vasectomy reversal; microsurgical varicocelectomy;... [more]

Choi, Jaehyuk

Choi, Jaehyuk

Assistant Professor of Dermatology and Biochemistry and Molecular Genetics

jaehyuk.choi( at )northwestern.edu

Description of Interests

We employ cutting-edge genomics approaches to identify the genetic basis of inherited and acquired immunological disorders and skin cancer. As an example, we have recently identified the genes and m... [more]

Datta, Syamal K

Datta, Syamal K

Professor Emeritus of Medicine (Rheumatology)

skd257( at )northwestern.edu

Description of Interests

Autoimmunity & Tolerance to Nucleosomes, Apoptosis, Peptide Epitope Therapy, Signaling Threshold, Lupus.

DiDonato, Christine J

DiDonato, Christine J

Associate Professor of Pediatrics (Human Molecular Genetics)

c-didonato( at )northwestern.edu

Description of Interests

My broad research interest lies in understanding the molecular basis of human genetic diseases and developing therapeutics for their treatment. Specifically, my research primarily focuses on neuromusc... [more]

Doglio, Lynn T

Doglio, Lynn T

Research Associate Professor of Pharmacology

Engman, David

Engman, David

Adjunct Professor of Pathology and Microbiology-Immunology

d-engman( at )northwestern.edu

Description of Interests

The Engman Laboratory conducts research in several areas: (1) Molecular genetics and cell biology of tropical parasitic infections with a focus on trypanosomes, single-celled eukaryotic pathogens cau... [more]

Garcia-Anoveros, Jaime

Garcia-Anoveros, Jaime

Associate Professor of Anesthesiology, Neurology - Ken and Ruth Davee Department and Physiology

anoveros( at )northwestern.edu

Description of Interests

Auditory nociception, hair cell, mechanosensory transduction, sensory organ development, function and degeneration.

George, Jr., Alfred  L.

George, Jr., Alfred L.

Professor of Pharmacology

al.george( at )northwestern.edu

Description of Interests

Our research program is focused on the structure, function, pharmacology, and molecular genetics of ion channels. His laboratory has contributed greatly to understanding the mechanisms by which ion ch... [more]

Gong, Shunyou

Gong, Shunyou

Assistant Professor of Pathology

Description of Interests

My clinical duties at the Lurie Children's Hospital of Chicago include signing out bone marrow and lymph node pathology reports, and directorship of the clinical hematology laboratory. My research int... [more]

Holmgren, Robert A

Holmgren, Robert A

Professor Molecular Biosciences PhD, Harvard University

r-holmgren( at )northwestern.edu

Description of Interests

Our work on signal transduction and gene expression is focused on the Hedgehog Hh signal transduction cascade and the Ci/Gli family of transcription factors.

Hsu, Pei-Ken

Hsu, Pei-Ken

Research Assistant Professor of Physiology

Kearney, Jennifer A

Kearney, Jennifer A

Associate Professor of Pharmacology

jennifer.kearney( at )northwestern.edu

Description of Interests

Research in my laboratory is focused on studying genetic modifiers that influence the clinical severity of epilepsy. Variable expressivity is a common feature in patients with epilepsy caused by sodiu... [more]

Kohtz, Jhumku D

Kohtz, Jhumku D

Research Professor of Pediatrics (Developmental Biology)

j-kohtz( at )northwestern.edu

Description of Interests

I have had a long-standing interest in studying RNA regulatory mechanisms in development. My lab has focused on studying the mechanism of action of Evfs, novel long non-coding RNAs that regulate trans... [more]

Kopp, Peter A

Kopp, Peter A

Professor of Medicine (Endocrinology)

p-kopp( at )northwestern.edu

Description of Interests

Dr. Kopp's research interests focus primarily on the genetic basis of endocrine disorders, in particular inborn errors of thyroid development and thyroid hormone synthesis, as well as disorders of wat... [more]

Kume, Tsutomu

Kume, Tsutomu

Professor of Medicine (Cardiology) and Pharmacology

Description of Interests

Dr. Kume's research interests focus on cardiovascular development, cardiovascular stem/progenitor cells, and angiogenesis. Current studies include the role of Foxc transcription factors in cardiovasc... [more]

LaBonne, Carole

LaBonne, Carole

Director, Interdepartmental Program in Biological Sciences (IBiS) Professor of Molecular Biosciences Weinberg College of Arts and Sciences

clabonne( at )northwestern.edu

Description of Interests

Our lab uses molecular genetic and genomic approaches to study the development of a group of embryonic cells called the neural crest. Neural crest cells are migratory, tissue-invasive stem cells that originate in the ectoderm of vertebrate embryos and play a central role in the development of the vertebrate body plan.

Langman, Craig B

Langman, Craig B

Professor of Pediatrics (Kidney Diseases)

c-langman( at )northwestern.edu

Description of Interests

The PI has three major areas of hypothesis-driven research that are studied and supported: urinary proteomics in genetic kidney stone diseases; mechanisms of progression in chronic kidney diseases; b... [more]

Lathem, Wyndham W

Lathem, Wyndham W

Associate Professor of Microbiology-Immunology

lathem( at )northwestern.edu

Description of Interests

Yersinia pestis and Yersinia pseudotuberculosis are two bacterial pathogens that are very closely related, yet cause vastly different diseases in the mammalian host. Y. pestis is infamous for causing ... [more]

Linzer, Daniel

Linzer, Daniel

Provost, Northwestern University, Professor of Biomolecular Sciences Weinberg College of Arts and Sciences

dlinzer( at )northwestern.edu

Description of Interests

The research of Dan Linzer’s laboratory demonstrates that the development of the mammalian fetus within the mother requires that mammalian reproduction and development be tightly linked. Changes in maternal physiology must occur to accommodate and nurture the fetus.

Lomasney, Jon W

Lomasney, Jon W

Associate Professor of Pathology and Pharmacology

Description of Interests

Autopsy pathology, Cardiac pathology <BR><BR> Lipids are important regulators of the activity of many proteins including those involved in cardiac, vascular, pulmonary, and neural regulation, yet lit... [more]

Longnecker, Richard M

Longnecker, Richard M

Professor of Microbiology-Immunology

r-longnecker( at )northwestern.edu

Description of Interests

Research in the Longnecker laboratory focuses on herpes simplex virus (HSV) and Epstein-Barr virus (EBV). These viruses typically cause self-limiting disease within the human population but both can ... [more]

Ma, Yongchao

Ma, Yongchao

Assistant Professor of Pediatrics (Developmental Biology), Neurology - Ken and Ruth Davee Department and Physiology

ma( at )northwestern.edu

Description of Interests

Regulation of Motor Neuron and Dopaminergic Neuron Function in Development and Disease -------- Spinal Motor Neurons and Spinal Muscular Atrophy (SMA): SMA is characterized by the selective degenerati... [more]

Mandel, Mark J

Mandel, Mark J

Associate Professor of Microbiology-Immunology

m-mandel( at )northwestern.edu

Description of Interests

The goal of my research is to understand the molecular basis by which animals and their natural microbiota form specific, reproducible interactions. Microbial symbioses are prevalent in animal biology... [more]

Mayo, Kelly

Mayo, Kelly

Associate Dean for Research and Graduate Studies Professor of Molecular Biosciences Weinberg College of Arts and Sciences

k-mayo( at )northwestern.edu

Description of Interests

Stochastic and discrete optimization algorithms; decision under uncertainty; healthcare systems; portfolio optimization

Meeks, Joshua J

Meeks, Joshua J

Assistant Professor of Urology and Obstetrics and Gynecology

Description of Interests

Dr. Meeks is an Assistant Professor of Urology at the Northwestern University Feinberg School of Medicine, as well as Section Chief of Robotic Surgery at the Jesse Brown VA Medical Center. He received... [more]

Miller, Stephen D

Miller, Stephen D

Professor of Microbiology-Immunology and Dermatology

s-d-miller( at )northwestern.edu

Description of Interests

The laboratory is interested in understanding the mechanisms underlying the pathogenesis and immunoregulation of T cell-mediated autoimmune diseases, allergic disease, and rejection of tissue and orga... [more]

Morimoto, Richard I

Morimoto, Richard I

Bill and Gayle Cook Professor of Biology Director, Rice Institute for Biomedical Research Department of Molecular Biosciences Weinberg College of Arts and Sciences

r-morimoto( at )northwestern.edu

Description of Interests

Our laboratory is interested in the fundamental events that underlie the appearance of misfolded proteins and their consequence to protein homeostasis, cellular function, and organismal adaptation and survival

Opal, Puneet

Opal, Puneet

Professor of Neurology (Movement Disorders) and Cell and Molecular Biology

Description of Interests

Ataxias, spinocerbellar ataxia, movement disorders, neurodegenerative diseases, stroke, cerebrovascular disorders.

Pachman, Lauren M

Pachman, Lauren M

Professor of Pediatrics (Rheumatology)

pachman( at )northwestern.edu

Description of Interests

Dr. Pachman's translational team studies Juvenile Myositis (JM), an often chronic pediatric systemic vasculopathy associated with skin inflammation and proximal muscle weakness of unknown etiology. He... [more]

Paller, Amy S

Paller, Amy S

Professor of Dermatology and Pediatrics (Dermatology)

apaller( at )northwestern.edu

Description of Interests

The Paller lab studies the role of topically-applied, nanotherapy based gene therapy to treat skin disease, particularly diabetic ulcers, psoriasis, atopic dermatitis (eczema), skin cancer, and rare g... [more]

Pinto, Lawrence

Pinto, Lawrence

Professor Emeritus, Department of Neurobiology Weinberg College of Arts and Sciences

Description of Interests

Dr. Pinto is the associate director of the Center for Functional Genomics, and he is interested in discovering the genes that are involved in biological processes. His main efforts employ chemical mutagenesis and screening for phenotypes of interest. The two phenotypes that he studies are vision and asthma.

Redei, Eva

Redei, Eva

Professor of Psychiatry and Behavioral Sciences and Physiology

Description of Interests

Dr. Eva Redei conducts research in the following categories: biomarkers, stress hypersensitivity, depressive disorders, genetic vulnerability, epigenetic regulation, imprinted genes, neuroendocrinolog... [more]

Saratsis, Amanda Muhs

Saratsis, Amanda Muhs

Assistant Professor of Neurological Surgery

Description of Interests

Dr. Saratsis has clinical appointments in the Departments of Neurological Surgery at Northwestern Memorial and Lurie Children's Hospitals, caring for children and adults with congenital disorders of t... [more]

Sarthy, Vijay

Sarthy, Vijay

Professor of Ophthalmology and Cell and Molecular Biology

vjsarthy( at )northwestern.edu

Description of Interests

Neuron-glia interactions in the retina; Roles of Müller (glia) cells in the pathogenesis of retinal degenerations and diabetic retinopathy.

Shea, Lonnie D

Shea, Lonnie D

Professor of Chemical and Biological Engineering

l-shea( at )northwestern.edu

Description of Interests

The Shea Lab works at the interface of regenerative medicine, biomaterials, and gene and drug delivery. The central theme for the various projects is creating synthetic environments which can be employed to molecularly dissect tissue formation or promote regeneration.

Tourtellotte, Warren G

Tourtellotte, Warren G

Professor of Pathology and Neurology - Ken and Ruth Davee Department

warren( at )northwestern.edu

Description of Interests

Anatomic Pathology, Neuropathology, Neuromuscular pathology<BR><BR> The early growth response (Egr) family of transcription factors are involved in cellular growth and differentiation and may play a ... [more]

Turek, Fred

Turek, Fred

Professor of Weinberg College of Arts and Sciences, Neurology - Ken and Ruth Davee Department and Psychiatry and Behavioral Sciences

fturek( at )northwestern.edu

Description of Interests

Research in the Turek laboratory is focused on the study of sleep and circadian rhythms, with special interest in identifying genes that regulate sleep and circadian rhythms. Ongoing work on sleep and... [more]

Vassar, Robert J

Vassar, Robert J

Professor of Cell and Molecular Biology

Description of Interests

Our research focuses on molecular and cellular mechanisms of Alzheimer's disease. In particular, we investigate the beta-secretase enzyme BACE1, which initiates the production of the beta-amyloid pept... [more]

Woloschak, Gayle E

Woloschak, Gayle E

Professor of Radiation Oncology and Radiology

g-woloschak( at )northwestern.edu

Description of Interests

My research is focused on two general areas: radiobiology and bionanotechnology. Work in radiobiology includes studies of the molecular biology of radiation responses, particularly radiation toxicitie... [more]

Woodruff, Teresa K

Woodruff, Teresa K

Professor of Obstetrics and Gynecology (Reproductive Science in Medicine), McCormick School of Engineering, Medical Social Sciences and Medicine (Endocrinology)

tkw( at )northwestern.edu

Description of Interests

Woodruff's role in understanding inhibin fluctuation in the ovary led to questions about ovarian follicle formation and persistence, which provides new ways to think about fertility preservation for y... [more]

Wu, Jane Y

Wu, Jane Y

Professor of Neurology (Neuromuscular Disease)

Description of Interests

My primary research interests are in molecular mechanisms of gene regulation, particularly those involved in neural development and neural degeneration. My lab is focusing on two areas, RNA regulation... [more]

Xu, Eugene Y

Xu, Eugene Y

Adjunct Professor of Obstetrics and Gynecology (Reproductive Science in Medicine) and Psychiatry and Behavioral Sciences

e-xu( at )northwestern.edu

Description of Interests

The overall goal of my research program is to understand the mechanisms of mammalian reproduction, in particular, how germline stem cells, meiosis and gamete differentiation, are regulated in mammals,... [more]

Yang, Guang-Yu

Yang, Guang-Yu

Professor of Pathology

g-yang( at )northwestern.edu

Description of Interests

Surgical Pathology<BR><BR> The long-term objective of our research is to study molecular mechanism and chemoprevention of chronic inflammation-driven carcinogenesis. The specific areas of interest are... [more]

Zhang, Ming

Zhang, Ming

Associate Professor of Biochemistry and Molecular Genetics

m-zhang( at )northwestern.edu

Description of Interests

The main focus of my research program is to study roles of tumor suppressors in normal development and in breast and prostate cancer progression, focusing on Maspin and an Ets transcription factor PDE... [more]

Zheng, Jing

Zheng, Jing

Associate Professor of Otolaryngology - Head and Neck Surgery

jzh215( at )northwestern.edu

Description of Interests

The long-term goal of my lab is to identify and investigate molecules that play important roles in mammalian hearing, thus to enrich our understanding of cochlear physiology, and to further develop a ... [more]