Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Publications

Below is a list of publications describing experimental analysis of genetically-modified mice generated by the Transgenic and Targeted Mutagenesis Laboratory.

  1. Smear M, Shusterman R, O'Connor R, Bozza T, & Rinberg D (2011) Perception of sniff phase in mouse olfaction. Nature 479(7373):397-400.

  2. Schultz KM, Banisadr G, Lastra RO, McGuire T, Kessler JA, Miller RJ, & McGarry TJ (2011) Geminin-deficient neural stem cells exhibit normal cell division and normal neurogenesis. PloS one 6(3):e17736.

  3. Rosenbaum JN, Duggan A, & Garcia-Anoveros J (2011) Insm1 promotes the transition of olfactory progenitors from apical and proliferative to basal, terminally dividing and neuronogenic. Neural development 6:6.

  4. Laronda MM & Jameson JL (2011) Sox3 functions in a cell-autonomous manner to regulate spermatogonial differentiation in mice. Endocrinology 152(4):1606-1615.

  5. Jin YH, Kang HS, Mohindru M, & Kim BS (2011) Preferential induction of protective T cell responses to Theiler's virus in resistant (C57BL/6 x SJL)F1 mice. Journal of virology 85(6):3033-3040.

  6. Castiglioni AJ, Remis NN, Flores EN, & Garcia-Anoveros J (2011) Expression and vesicular localization of mouse Trpml3 in stria vascularis, hair cells, and vomeronasal and olfactory receptor neurons. The Journal of comparative neurology 519(6):1095-1114.

  7. Bai L, Jia Y, Viswakarma N, Huang J, Vluggens A, Wolins NE, Jafari N, Rao MS, Borensztajn J, Yang G, & Reddy JK (2011) Transcription coactivator mediator subunit MED1 is required for the development of fatty liver in the mouse. Hepatology 53(4):1164-1174.

  8. Zhou J, Yi J, Fu R, Liu E, Siddique T, Rios E, & Deng HX (2010) Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis. The Journal of biological chemistry 285(1):705-712.

  9. Vluggens A, Andreoletti P, Viswakarma N, Jia Y, Matsumoto K, Kulik W, Khan M, Huang J, Guo D, Yu S, Sarkar J, Singh I, Rao MS, Wanders RJ, Reddy JK, & Cherkaoui-Malki M (2010) Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]. Laboratory investigation; a journal of technical methods and pathology 90(5):696-708.

  10. Viswakarma N, Jia Y, Bai L, Vluggens A, Borensztajn J, Xu J, & Reddy JK (2010) Coactivators in PPAR-Regulated Gene Expression. PPAR research 2010.

  11. VanGompel MJ & Xu EY (2010) A novel requirement in mammalian spermatid differentiation for the DAZ-family protein Boule. Human molecular genetics 19(12):2360-2369.

  12. Stumpf M, Yue X, Schmitz S, Luche H, Reddy JK, & Borggrefe T (2010) Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1. Proceedings of the National Academy of Sciences of the United States of America 107(50):21541-21546.

  13. Shinnick KM, Eklund EA, & McGarry TJ (2010) Geminin deletion from hematopoietic cells causes anemia and thrombocytosis in mice. The Journal of clinical investigation 120(12):4303-4315.

  14. Shah C, Vangompel MJ, Naeem V, Chen Y, Lee T, Angeloni N, Wang Y, & Xu EY (2010) Widespread presence of human BOULE homologs among animals and conservation of their ancient reproductive function. PLoS genetics 6(7):e1001022.

  15. Rainey MA, George M, Ying G, Akakura R, Burgess DJ, Siefker E, Bargar T, Doglio L, Crawford SE, Todd GL, Govindarajan V, Hess RA, Band V, Naramura M, & Band H (2010) The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in mice. BMC developmental biology 10:37

  16. Pyper SR, Viswakarma N, Yu S, & Reddy JK (2010) PPARalpha: energy combustion, hypolipidemia, inflammation and cancer. Nuclear receptor signaling 8:e002.

  17. Matsumoto K, Huang J, Viswakarma N, Bai L, Jia Y, Zhu YT, Yang G, Borensztajn J, Rao MS, Zhu YJ, & Reddy JK (2010) Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse. Carcinogenesis 31(2):318-325.

  18. Harris RM, Finlayson C, Weiss J, Fisher L, Hurley L, Barrett T, Emge D, Bathgate RA, Agoulnik AI, & Jameson JL (2010) A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism. Mammalian genome : official journal of the International Mammalian Genome Society 21(9-10):442-449.

  19. Guzman JN, Sanchez-Padilla J, Wokosin D, Kondapalli J, Ilijic E, Schumacker PT, & Surmeier DJ (2010) Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468(7324):696-700.

  20. Xiao W, Ai J, Habermacher G, Volpert O, Yang X, Zhang AY, Hahn J, Cai X, & Wang Z (2009) U19/Eaf2 binds to and stabilizes von hippel-lindau protein. Cancer research 69(6):2599-2606.

  21. Wu M, Melichian DS, de la Garza M, Gruner K, Bhattacharyya S, Barr L, Nair A, Shahrara S, Sporn PH, Mustoe TA, Tourtellotte WG, & Varga J (2009) Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing. The American journal of pathology 175(3):1041-1055

  22. McGarry TJ, Bonaguidi M, Lyass L, Kessler JA, Bodily JM, & Doglio L (2009) Enucleation of feeder cells and egg cells with psoralens. Developmental dynamics : an official publication of the American Association of Anatomists 238(10):2614-2621.

  23. Kim JH, Gurumurthy CB, Naramura M, Zhang Y, Dudley AT, Doglio L, Band H, & Band V (2009) Role of mammalian Ecdysoneless in cell cycle regulation. The Journal of biological chemistry 284(39):26402-26410.

  24. Jia Y, Viswakarma N, Fu T, Yu S, Rao MS, Borensztajn J, & Reddy JK (2009) Conditional ablation of mediator subunit MED1 (MED1/PPARBP) gene in mouse liver attenuates glucocorticoid receptor agonist dexamethasone-induced hepatic steatosis. Gene expression 14(5):291-306.

  25. Hou W, Kang HS, & Kim BS (2009) Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection. The Journal of experimental medicine 206(2):313-328.

  26. Xiao W, Zhang Q, Habermacher G, Yang X, Zhang AY, Cai X, Hahn J, Liu J, Pins M, Doglio L, Dhir R, Gingrich J, & Wang Z (2008) U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. Oncogene 27(11):1536-1544.

  27. Myoung J, Bahk YY, Kang HS, Dal Canto MC, & Kim BS (2008) Anticapsid immunity level, not viral persistence level, correlates with the progression of Theiler's virus-induced demyelinating disease in viral P1-transgenic mice. Journal of virology 82(11):5606-5617.

  28. Huang QQ, Hossain MM, Wu K, Parai K, Pope RM, & Jin JP (2008) Role of H2-calponin in regulating macrophage motility and phagocytosis. The Journal of biological chemistry 283(38):25887-25899.

  29. Eldredge LC, Gao XM, Quach DH, Li L, Han X, Lomasney J, & Tourtellotte WG (2008) Abnormal sympathetic nervous system development and physiological dysautonomia in Egr3-deficient mice. Development 135(17):2949-2957.

  30. Deng HX, Jiang H, Fu R, Zhai H, Shi Y, Liu E, Hirano M, Dal Canto MC, & Siddique T (2008) Molecular dissection of ALS-associated toxicity of SOD1 in transgenic mice using an exon-fusion approach. Human molecular genetics 17(15):2310-2319.

  31. Wojcik H GE, Staggs S, Hagman J and Winandi S. (2007) Expression of a non-DNA-binding Ikaros isoform exclusively in B cells leads to autoimmunity but not leukemogenesis. Eur J Imm 37(4):1022-1032.

  32. Li L, Yun SH, Keblesh J, Trommer BL, Xiong H, Radulovic J, & Tourtellotte WG (2007) Egr3, a synaptic activity regulated transcription factor that is essential for learning and memory. Molecular and cellular neurosciences 35(1):76-88.

  33. Wang Z, Qi C, Krones A, Woodring P, Zhu X, Reddy JK, Evans RM, Rosenfeld MG, & Hunter T (2006) Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. Cell metabolism 3(2):111-122.

  34. Swanson-Mungerson M, Bultema R, & Longnecker R (2006) Epstein-Barr virus LMP2A enhances B-cell responses in vivo and in vitro. Journal of virology 80(14):6764-6770.

  35. Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, & Disterhoft JF (2006) Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1. The European journal of neuroscience 23(1):251-260.

  36. Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, & Vassar R (2006) Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. The Journal of neuroscience : the official journal of the Society for Neuroscience 26(40):10129-10140.

  37. O'Brien JE, Peterson TJ, Tong MH, Lee EJ, Pfaff LE, Hewitt SC, Korach KS, Weiss J, & Jameson JL (2006) Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor alpha binding to classical estrogen response elements. The Journal of biological chemistry 281(36):26683-26692.

  38. Guo D, Sarkar J, Ahmed MR, Viswakarma N, Jia Y, Yu S, Sambasiva Rao M, & Reddy JK (2006) Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver. Biochemical and biophysical research communications 347(2):485-495.

  39. Deng HX, Shi Y, Furukawa Y, Zhai H, Fu R, Liu E, Gorrie GH, Khan MS, Hung WY, Bigio EH, Lukas T, Dal Canto MC, O'Halloran TV, & Siddique T (2006) Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria. Proceedings of the National Academy of Sciences of the United States of America 103(18):7142-7147.

  40. Whitehead J, Keller-Peck C, Kucera J, & Tourtellotte WG (2005) Glial cell-line derived neurotrophic factor-dependent fusimotor neuron survival during development. Mechanisms of development 122(1):27-41.

  41. Syed FA, Modder UI, Fraser DG, Spelsberg TC, Rosen CJ, Krust A, Chambon P, Jameson JL, & Khosla S (2005) Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20(11):1992-2001.

  42. Swanson-Mungerson MA, Caldwell RG, Bultema R, & Longnecker R (2005) Epstein-Barr virus LMP2A alters in vivo and in vitro models of B-cell anergy, but not deletion, in response to autoantigen. Journal of virology 79(12):7355-7362.

  43. Stefan M, Portis T, Longnecker R, & Nicholls RD (2005) A nonimprinted Prader-Willi Syndrome (PWS)-region gene regulates a different chromosomal domain in trans but the imprinted pws loci do not alter genome-wide mRNA levels. Genomics 85(5):630-640.

  44. Stefan M, Claiborn KC, Stasiek E, Chai JH, Ohta T, Longnecker R, Greally JM, & Nicholls RD (2005) Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes. BMC genomics 6:157.

  45. Singh AJ, Meyer RD, Band H, & Rahimi N (2005) The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation. Molecular biology of the cell 16(4):2106-2118.

  46. Raverot G, Weiss J, Park SY, Hurley L, & Jameson JL (2005) Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis. Developmental biology 283(1):215-225.

  47. Li L, Carter J, Gao X, Whitehead J, & Tourtellotte WG (2005) The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors. Molecular and cellular biology 25(23):10286-10300.

  48. Lakiza O, Frater L, Yoo Y, Villavicencio E, Walterhouse D, Goodwin EB, & Iannaccone P (2005) STAR proteins quaking-6 and GLD-1 regulate translation of the homologues GLI1 and tra-1 through a conserved RNA 3'UTR-based mechanism. Developmental biology 287(1):98-110.

  49. Jia Y, Qi C, Zhang Z, Zhu YT, Rao SM, & Zhu YJ (2005) Peroxisome proliferator-activated receptor-binding protein null mutation results in defective mammary gland development. The Journal of biological chemistry 280(11):10766-10773.

  50. Jia Y, Guo GL, Surapureddi S, Sarkar J, Qi C, Guo D, Xia J, Kashireddi P, Yu S, Cho YW, Rao MS, Kemper B, Ge K, Gonzalez FJ, & Reddy JK (2005) Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity. Proceedings of the National Academy of Sciences of the United States of America 102(35):12531-12536.

  51. Ikeda M & Longnecker R (2005) Pre-B-cell colony formation assay. Methods Mol Biol 292:279-284.

  52. Freedman BD, Lee EJ, Park Y, & Jameson JL (2005) A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome. The Journal of biological chemistry 280(17):17118-17125.

  53. Dimri G, Band H, & Band V (2005) Mammary epithelial cell transformation: insights from cell culture and mouse models. Breast cancer research : BCR 7(4):171-179.

  54. Bristol-Gould SK, Hutten CG, Sturgis C, Kilen SM, Mayo KE, & Woodruff TK (2005) The development of a mouse model of ovarian endosalpingiosis. Endocrinology 146(12):5228-5236.

  55. Albert Y, Whitehead J, Eldredge L, Carter J, Gao X, & Tourtellotte WG (2005) Transcriptional regulation of myotube fate specification and intrafusal muscle fiber morphogenesis. The Journal of cell biology 169(2):257-268.

  56. Somwaru L, Li S, Doglio L, Goldberg E, & Zirkin BR (2004) Heat-induced apoptosis of mouse meiotic cells is suppressed by ectopic expression of testis-specific calpastatin. Journal of andrology 25(4):506-513.

  57. Qi C, Kashireddy P, Zhu YT, Rao SM, & Zhu YJ (2004) Null mutation of peroxisome proliferator-activated receptor-interacting protein in mammary glands causes defective mammopoiesis. The Journal of biological chemistry 279(32):33696-33701.

  58. Portis T & Longnecker R (2004) Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway. Oncogene 23(53):8619-8628.

  59. Portis T & Longnecker R (2004) Epstein-Barr virus (EBV) LMP2A alters normal transcriptional regulation following B-cell receptor activation. Virology 318(2):524-533.

  60. Meng G, Zhao Y, Nag A, Zeng M, Dimri G, Gao Q, Wazer DE, Kumar R, Band H, & Band V (2004) Human ADA3 binds to estrogen receptor (ER) and functions as a coactivator for ER-mediated transactivation. The Journal of biological chemistry 279(52):54230-54240.

  61. Jia Y, Qi C, Kashireddi P, Surapureddi S, Zhu YJ, Rao MS, Le Roith D, Chambon P, Gonzalez FJ, & Reddy JK (2004) Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. The Journal of biological chemistry 279(23):24427-24434.

  62. Ikeda A, Merchant M, Lev L, Longnecker R, & Ikeda M (2004) Latent membrane protein 2A, a viral B cell receptor homologue, induces CD5+ B-1 cell development. J Immunol 172(9):5329-5337.

  63. Ghosh AK, Reddi AL, Rao NL, Duan L, Band V, & Band H (2004) Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase. The Journal of biological chemistry 279(34):36132-36141.

  64. Feshchenko EA, Smirnova EV, Swaminathan G, Teckchandani AM, Agrawal R, Band H, Zhang X, Annan RS, Carr SA, & Tsygankov AY (2004) TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin. Oncogene 23(27):4690-4706.

  65. Fernandis AZ, Prasad A, Band H, Klosel R, & Ganju RK (2004) Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells. Oncogene 23(1):157-167.

  66. Chu R, Lim H, Brumfield L, Liu H, Herring C, Ulintz P, Reddy JK, & Davison M (2004) Protein profiling of mouse livers with peroxisome proliferator-activated receptor alpha activation. Molecular and cellular biology 24(14):6288-6297.

  67. Zhu YJ, Crawford SE, Stellmach V, Dwivedi RS, Rao MS, Gonzalez FJ, Qi C, & Reddy JK (2003) Coactivator PRIP, the peroxisome proliferator-activated receptor-interacting protein, is a modulator of placental, cardiac, hepatic, and embryonic development. The Journal of biological chemistry 278(3):1986-1990.

  68. Yu S, Matsusue K, Kashireddy P, Cao WQ, Yeldandi V, Yeldandi AV, Rao MS, Gonzalez FJ, & Reddy JK (2003) Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression. The Journal of biological chemistry 278(1):498-505.

  69. Weiss J, Meeks JJ, Hurley L, Raverot G, Frassetto A, & Jameson JL (2003) Sox3 is required for gonadal function, but not sex determination, in males and females. Molecular and cellular biology 23(22):8084-8091.

  70. Swanson-Mungerson M, Ikeda M, Lev L, Longnecker R, & Portis T (2003) Identification of latent membrane protein 2A (LMP2A) specific targets for treatment and eradication of Epstein-Barr virus (EBV)-associated diseases. The Journal of antimicrobial chemotherapy 52(2):152-154.

  71. Russell TA, Ito M, Ito M, Yu RN, Martinson FA, Weiss J, & Jameson JL (2003) A murine model of autosomal dominant neurohypophyseal diabetes insipidus reveals progressive loss of vasopressin-producing neurons. The Journal of clinical investigation 112(11):1697-1706.

  72. Portis T & Longnecker R (2003) Epstein-Barr virus LMP2A interferes with global transcription factor regulation when expressed during B-lymphocyte development. Journal of virology 77(1):105-114.

  73. Portis T, Dyck P, & Longnecker R (2003) Epstein-Barr Virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphoma. Blood 102(12):4166-4178.

  74. Meeks JJ, Russell TA, Jeffs B, Huhtaniemi I, Weiss J, & Jameson JL (2003) Leydig cell-specific expression of DAX1 improves fertility of the Dax1-deficient mouse. Biology of reproduction 69(1):154-160.

  75. Kuzmanovic M, Dudley VJ, & Sarthy VP (2003) GFAP promoter drives Muller cell-specific expression in transgenic mice. Investigative ophthalmology & visual science 44(8):3606-3613.

  76. Kroft TL, Li S, Doglio L, & Goldberg E (2003) A transgenic analysis of mouse lactate dehydrogenase C promoter activity in the testis. Journal of andrology 24(6):843-852.

  77. Jia Y, Qi C, Zhang Z, Hashimoto T, Rao MS, Huyghe S, Suzuki Y, Van Veldhoven PP, Baes M, & Reddy JK (2003) Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal beta-oxidation system. The Journal of biological chemistry 278(47):47232-47239.

  78. Ikeda A, Caldwell RG, Longnecker R, & Ikeda M (2003) Itchy, a Nedd4 ubiquitin ligase, downregulates latent membrane protein 2A activity in B-cell signaling. Journal of virology 77(9):5529-5534.

  79. Siddique T & Lalani I (2002) Genetic aspects of amyotrophic lateral sclerosis. Advances in neurology 88:21-32.

  80. Portis T, Cooper L, Dennis P, & Longnecker R (2002) The LMP2A signalosome--a therapeutic target for Epstein-Barr virus latency and associated disease. Frontiers in bioscience : a journal and virtual library 7:d414-426.

  81. Narula A, Kilen S, Ma E, Kroeger J, Goldberg E, & Woodruff TK (2002) Smad4 overexpression causes germ cell ablation and leydig cell hyperplasia in transgenic mice. The American journal of pathology 161(5):1723-1734.

  82. Jakacka M, Ito M, Martinson F, Ishikawa T, Lee EJ, & Jameson JL (2002) An estrogen receptor (ER)alpha deoxyribonucleic acid-binding domain knock-in mutation provides evidence for nonclassical ER pathway signaling in vivo. Mol Endocrinol 16(10):2188-2201.

  83. Ikeda M, Ikeda A, & Longnecker R (2002) Lysine-independent ubiquitination of Epstein-Barr virus LMP2A. Virology 300(1):153-159.

  84. Crawford SE, Qi C, Misra P, Stellmach V, Rao MS, Engel JD, Zhu Y, & Reddy JK (2002) Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. The Journal of biological chemistry 277(5):3585-3592.

  85. Cooper L & Longnecker R (2002) Inhibition of host kinase activity altered by the LMP2A signalosome-a therapeutic target for Epstein-Barr virus latency and associated disease. Antiviral research 56(3):219-231.

  86. Chen HH, Tourtellotte WG, & Frank E (2002) Muscle spindle-derived neurotrophin 3 regulates synaptic connectivity between muscle sensory and motor neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 22(9):3512-3519.

  87. McMullen ML, Cho BN, Yates CJ, & Mayo KE (2001) Gonadal pathologies in transgenic mice expressing the rat inhibin alpha-subunit. Endocrinology 142(11):5005-5014.

  88. Ma GT, Soloveva V, Tzeng SJ, Lowe LA, Pfendler KC, Iannaccone PM, Kuehn MR, & Linzer DI (2001) Nodal regulates trophoblast differentiation and placental development. Developmental biology 236(1):124-135.

  89. Kroft TL, Patterson J, Won Yoon J, Doglio L, Walterhouse DO, Iannaccone PM, & Goldberg E (2001) GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene. Biology of reproduction 65(6):1663-1671.

  90. Jeffs B, Ito M, Yu RN, Martinson FA, Wang ZJ, Doglio LT, & Jameson JL (2001) Sertoli cell-specific rescue of fertility, but not testicular pathology, in Dax1 (Ahch)-deficient male mice. Endocrinology 142(6):2481-2488.

  91. Huo L & Scarpulla RC (2001) Mitochondrial DNA instability and peri-implantation lethality associated with targeted disruption of nuclear respiratory factor 1 in mice. Molecular and cellular biology 21(2):644-654.

  92. Cho BN, McMullen ML, Pei L, Yates CJ, & Mayo KE (2001) Reproductive deficiencies in transgenic mice expressing the rat inhibin alpha-subunit gene. Endocrinology 142(11):4994-5004.

  93. Zhu Y, Qi C, Jia Y, Nye JS, Rao MS, & Reddy JK (2000) Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality. The Journal of biological chemistry 275(20):14779-14782.

  94. Wilsbacher LD, Sangoram AM, Antoch MP, & Takahashi JS (2000) The mouse Clock locus: sequence and comparative analysis of 204 kb from mouse chromosome 5. Genome research 10(12):1928-1940.

  95. Nguyen LQ, Kopp P, Martinson F, Stanfield K, Roth SI, & Jameson JL (2000) A dominant negative CREB (cAMP response element-binding protein) isoform inhibits thyrocyte growth, thyroid-specific gene expression, differentiation, and function. Mol Endocrinol 14(9):1448-1461.

  96. Merchant M, Caldwell RG, & Longnecker R (2000) The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo. Journal of virology 74(19):9115-9124.

  97. Longan L & Longnecker R (2000) Epstein-Barr virus latent membrane protein 2A has no growth-altering effects when expressed in differentiating epithelia. The Journal of general virology 81(Pt 9):2245-2252.

  98. Li S & Goldberg E (2000) A novel N-terminal domain directs membrane localization of mouse testis-specific calpastatin. Biology of reproduction 63(6):1594-1600.

  99. Kundu SD, Kim IY, Yang T, Doglio L, Lang S, Zhang X, Buttyan R, Kim SJ, Chang J, Cai X, Wang Z, & Lee C (2000) Absence of proximal duct apoptosis in the ventral prostate of transgenic mice carrying the C3(1)-TGF-beta type II dominant negative receptor. The Prostate 43(2):118-124.

  100. Deng HX & Siddique T (2000) Transgenic mouse models and human neurodegenerative disorders. Archives of neurology 57(12):1695-1702.

  101. Caldwell RG, Brown RC, & Longnecker R (2000) Epstein-Barr virus LMP2A-induced B-cell survival in two unique classes of EmuLMP2A transgenic mice. Journal of virology 74(3):1101-1113.

  102. Gabriel JM, Merchant M, Ohta T, Ji Y, Caldwell RG, Ramsey MJ, Tucker JD, Longnecker R, & Nicholls RD (1999) A transgene insertion creating a heritable chromosome deletion mouse model of Prader-Willi and angelman syndromes. Proceedings of the National Academy of Sciences of the United States of America 96(16):9258-9263.

  103. Yu RN, Ito M, Saunders TL, Camper SA, & Jameson JL (1998) Role of Ahch in gonadal development and gametogenesis. Nature genetics 20(4):353-357.

  104. Siklos L, Engelhardt JI, Alexianu ME, Gurney ME, Siddique T, & Appel SH (1998) Intracellular calcium parallels motoneuron degeneration in SOD-1 mutant mice. Journal of neuropathology and experimental neurology 57(6):571-587.

  105. Li S, Zhou W, Doglio L, & Goldberg E (1998) Transgenic mice demonstrate a testis-specific promoter for lactate dehydrogenase, LDHC. The Journal of biological chemistry 273(47):31191-31194.

  106. Caldwell RG, Wilson JB, Anderson SJ, & Longnecker R (1998) Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals. Immunity 9(3):405-411.

  107. Kostic V, Gurney ME, Deng HX, Siddique T, Epstein CJ, & Przedborski S (1997) Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. Annals of neurology 41(4):497-504.