Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Steven J Lubbe, PhD

Steven J Lubbe, PhD

Assistant Professor of Neurology (Movement Disorders)

Focus of Work

Bio

I am interested in using bioinformatic analysis of next generation sequencing, GWAS data and rare variant genotype data to further our understanding of the genomics of Parkinson's disease, dystonia and other movement disorders. The main aim of my lab is to identify novel variants and/or genes associated with disease causality or disease susceptibility, as well as investigating potential genetic modifiers of disease onset and/or progression. Candidate variants/genes will be investigated functiona...[Read full text]I am interested in using bioinformatic analysis of next generation sequencing, GWAS data and rare variant genotype data to further our understanding of the genomics of Parkinson's disease, dystonia and other movement disorders. The main aim of my lab is to identify novel variants and/or genes associated with disease causality or disease susceptibility, as well as investigating potential genetic modifiers of disease onset and/or progression. Candidate variants/genes will be investigated functionally to elucidate their direct role in disease etiology. The epidemiological link between Parkinson's disease and cancers, particularly cutaneous malignant melanoma, will also be investigated to identify genes/variants that influence risk to both diseases. The role of pigmentation in Parkinson's disease pathogenesis is another area that I plan to focus on.[Shorten text]

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Education and Certification

  • MSc: University of Witwatersrand, South Africa, Human Genetics (2004)
  • PhD: Institute of Cancer Research, United Kingdom, Genetics (2011)