Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Aaron  Hamvas, MD

Aaron Hamvas, MD

Chief of Neonatology in the Department of Pediatrics

Raymond & Hazel Speck Berry Professor of Neonatology

Professor of Pediatrics (Neonatology)

Focus of Work

Bio

Our laboratory is interested in understanding the genetic contributions to lung diseases that affect newborns, children and adults. Mutations in pulmonary surfactant associated genes result in newborn respiratory distress but can also contribute to idiopathic pulmonary fibrosis in adults. In addition, mutations in a transcription factor, FOXF1, are responsible for pulmonary vascular maldevelopment and lethal pulmonary hypertension in newborns. We utilize high throughput sequencing technology and...[Read full text]Our laboratory is interested in understanding the genetic contributions to lung diseases that affect newborns, children and adults. Mutations in pulmonary surfactant associated genes result in newborn respiratory distress but can also contribute to idiopathic pulmonary fibrosis in adults. In addition, mutations in a transcription factor, FOXF1, are responsible for pulmonary vascular maldevelopment and lethal pulmonary hypertension in newborns. We utilize high throughput sequencing technology and cell-based systems to identify the genetic basis for these disorders, test the mechanisms by which these genes function, and understand the variability in disease penetrance in families. We are also interested in understanding genes and gene pathways that might contribute to the development of chronic lung disease (bronchopulmonary dysplasia) in premature newborns and are exploring exome sequencing data for 400 infants. We collaborate with experts in bioinformatics and statistical genomics to analyze genomic data for insights into biological mechanisms. Finally, in collaboration with Dr. Debra Weese-Mayer of Pediatric Autonomic Medicine, we are beginning a study in the Lurie Children's and Prentice Women's Hospitals NICUs to investigate autonomic development and control of breathing in premature newborns.[Shorten text]

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Education and Certification

  • MD: Washington University (1981)
  • Residency: Saint Louis Children's Hospital, Pediatrics (1984)
  • Fellowship: Saint Louis Children's Hospital, Pediatrics (1990)
  • Board Certification: Neonatal-Perinatal Medicine

Contact

312-227-4190

Ann & Robert H. Lurie Children's Hospital of Chicago Box 45
225 E Chicago Avenue
Chicago IL 60611