Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Dimitri  Krainc, MD, PhD

Dimitri Krainc, MD, PhD

Chair, Department of Neurology
Director, Center for Rare Neurological Diseases (CRND)

Aaron Montgomery Ward Professor

Professor of Neurology (Movement Disorders), Neurological Surgery, Physiology and Weinberg College of Arts and Sciences


Administrative office: 312-503-3936
Clinic (for patients): 312-695-7950

Ward Building Room 12-140
303 E Chicago Avenue
Chicago IL 60611

Education/Research Website

Hospital Affiliations

I am on the medical staff at the following Feinberg-affiliated hospital(s)

Education and Certification

MD: University of Zagreb (1992)
PhD: Harvard Medical School, Neurobiology (1996)
Residency: Massachusetts General Hospital and Brigham and Women’s Hospital, Harvard Medical School, Neurology (2000)
Fellowship: Massachusetts General Hospital and Brigham and Women’s Hospital, Harvard Medical School, Movement Disorders (2002)
Board Certification: Neurology


Description of Interests

The overarching goal of our scientific work has been to define key molecular pathways in the pathogenesis of neurodegeneration and to uncover novel targets for therapeutic development. We have focused on pathogenic mechanisms that are commonly altered in neurodegenerative disorders such as deficient degradation of aggregation-prone proteins and mitochondrial dysfunction. As a general strategy, we study rare genetic diseases with mutations in genes that play a role in these key mechanisms and pathways. Models of Huntington’s, Parkinson’s and Gaucher’s disease have been utilized to examine if activation of cellular degradation pathways can lead to neuroprotection. To validate and study these findings in human neurons, we utilize induced pluripotent stem cells (iPS) generated by reprogramming of patient-specific skin fibroblasts. These iPS cells are differentiated into specific neuronal subtypes in order to characterize the interplay of genetic, epigenetic and environmental factors in disease pathogenesis. The ultimate goal of these studies is to develop targeted therapies for Parkinson’s and related neurodegenerative disorders.

Interests (Keywords)

Aging; Alzheimer's Disease; Gene Regulation; Movement Disorders; Neurogenetics; Neurology; Neuroscience; Parkinson’s disease

Research and Publications

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