Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Hans-Georg  Simon, PhD

Hans-Georg Simon, PhD

Associate Professor of Pediatrics (Developmental Behavioral Pediatrics)



Stanley Manne Children’s Research Institute Box 204
225 East Chicago Avenue
Chicago IL 60611

hgsimon( at )

Education/Research Website

Education and Certification

PhD: University of Freiburg, Biology (1988)


Description of Interests

Building And Re-Building Of Limbs And Hearts. The Simon laboratory has identified regulatory genes that play key roles in limb development in virtually all vertebrates, including humans. Surprisingly, these genes are also critical for the shaping of the heart during embryogenesis and when mutated in humans, they lead to birth defects of the arms and heart. Using zebrafish and mouse models, the lab tries to gain a deeper understanding of common genetic pathways in limb and heart development and disease. In addition to these developmental studies, the lab is interested in discovering the genes that are involved in regenerative processes. As models for these investigations, zebrafish and newts are employed, which can regenerate limbs and heart ventricles throughout their life times. The identification of genetic pathways that are operational in these regenerating species, but not in mammals, will provide new insights how to restore regenerative abilities in non-regenerating species including humans.

Interests (Keywords)

Blood/Bleeding Disorders (anemia, clotting, etc.); Cell Biology; Congenital Heart Disease; Cytoskeleton; Developmental biology; Extracellular Matrix; Regenerative Medicine; Stem Cells

Research and Publications

Northwestern Scholars

View the Hans-Georg Simon Northwestern Scholars profile.

Northwestern Scholars is a searchable database including faculty profiles, publications, and grant data from across all Northwestern University disciplines. It connects faculty members from all disciplines across Northwestern University to new research opportunities and collaborations at Northwestern.


Institutes and Centers

Feinberg's institutes and centers facilitate collaboration on scientific problems, research, and educational initiatives. I am a member of the following institutes and centers:



Edit My Profile

Northwestern medical faculty can update their faculty profile any time and as often as they like using the web-based, secure platform. It is the responsibility of faculty members to add content and build a profile that reflects their contributions to Feinberg and their specialty.