Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Liming  Li, PhD

Liming Li, PhD

Associate Professor of Biochemistry and Molecular Genetics

Focus of Work

Bio

Prion proteins are capable of existing in multiple stable conformations, at least one of which is infectious. It is generally accepted that prion (PrPSc) is the responsible agent for the devastating neurodegenerative disorders known as transmissible spongiform encephalopathies or prion diseases. Our laboratory is interested in using yeast and other model organisms to understand how a prion protein acquires its infectious prion conformations and how such conformations are maintained in vivo. Our ...[Read full text]Prion proteins are capable of existing in multiple stable conformations, at least one of which is infectious. It is generally accepted that prion (PrPSc) is the responsible agent for the devastating neurodegenerative disorders known as transmissible spongiform encephalopathies or prion diseases. Our laboratory is interested in using yeast and other model organisms to understand how a prion protein acquires its infectious prion conformations and how such conformations are maintained in vivo. Our ultimate goal is to dissect the initiation and propagation processes of prionogenesis, and to identify important cellular factors required in each of these processes[Shorten text]

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Education and Certification

  • PhD: University of California-Davis (1992)
  • Postdoctoral Fellowship: Harvard University (1997)
  • Postdoctoral Fellowship: University of Chicago (2002)

Contact

312-503-4420
312-503-4421

Searle Building Room 7-625
320 E Superior
Chicago IL 60611