Katherine A. High, MD
Genetic Therapies for Genetic Disease: Clinical Successes and New Technologies Spark a Renaissance
Gene therapy – changing the DNA of a patient to permanently cure a disease – has been dreamed of since DNA was discovered. However, realizing this possibility has been a long road punctuated with high profile setbacks. Nonetheless, with recent clinical successes and the advent of powerful new technologies, gene therapy is poised for explosive advancement. Katherine A. High, MD, President and Chief Scientific Officer, Spark Therapeutics; and Member, Center for Cellular and Molecular Therapeutics at The Children's Hospital of Philadelphia, discusses the evolution of gene therapy in both the academic and commercial spheres, innovative alternatives to the traditional models for bringing research out of not-for-profit labs and into commercial production, and how exciting new genome editing and stem cell technologies are impacting the future of gene therapy.
Susan Lynch, PhD
November 5, 2014
The Microbiome: A New Frontier In Human Health
Traditionally the medical community has viewed microbes as the cause of illness and sought to eliminate them. This notion, however, is shifting as emerging research in the field of human microbiome research has revealed the presence of diverse microorganisms living on and within the human body. These complex microbial communities develop during infancy and produce a range of essential functions necessary for maintenance of human health. Susan Lynch, PhD, Associate Professor of Medicine, Director Colitis and Crohn's Disease Microbiome Research Core, Division of Gastroenterology, Department of Medicine, University of California San Francisco, discusses the genesis, influences on and effects of the human microbiome, with a particular focus on childhood allergic disease and asthma.
Max S. Wicha, MD
May 21, 2014
Cancer Stem Cells: Are We Targeting the Right Cells?
Why do tumors reemerge in so many cancer patients? Current cancer treatments target the cells that make up the bulk of a tumor, but may miss the cells that cause metastasis and relapse. Recent evidence suggests that many cancers, including breast cancer, are driven by a small subpopulation of “cancer stem cells" that are relatively resistant to radiation and chemotherapy. Max S. Wicha, MD, Distinguished Professor of Oncology and Director, University of Michigan Comprehensive Cancer Center, discusses the “cancer stem cell” model and its implications to the biology and treatment of tumors, including the early clinical trials of treatments that specifically target cancer stem cells.
Fred W. Turek, PhD
Genetics of Circadian Rhythms and Sleep: Modern Life Battles Ancient Drives and Mother Nature
Circadian (24-hour) rhythms and the sleep-wake cycle have evolved over millions of years to allow animals to function optimally at different times of the day and night. However, with the emergence of a 24-hour lifestyle, modern humans ignore Mother Nature’s instructions and try to override our internal biological clock and sleep drive. Fred W. Turek, PhD, Charles E. & Emma H. Morrison Professor of Biology, Departments of Neurobiology & Neurology and Director, Center for Sleep & Circadian Biology, Northwestern University, discusses consequences of "fighting the clock", as well as rapid recent advances in understanding the machinery that underlies circadian rhythms and the control of sleep.
Louis J. Guillette Jr. PhD
Endocrine Disrupting Contaminants and Reproductive Health: Alligators as Canaries in a Coal Mine
Louis J. Guillette Jr. PhD, Director, Marine Biomedicine & Environmental Sciences Center; Professor of Obstetrics and Gynecology, Medical University of South Carolina; Centers of Economic Excellence (CoEE) Endowed Chair of Marine Genomics, Hollings Marine Laboratory; and Professor, Howard Hughes Medical Institute, reviews the work done in his laboratory and others examining the effects of various environmental contaminants on the development and functioning of the ovary and reproductive system at the gene to organ level.
Marc S. Williams, MD
Personal Genome Sequencing
Marc S. Williams, MD, Director, Geisinger Health System Genomic Medicine Institute, explores the emerging applications, benefits, and potential harms of personal genome sequencing. Dr. Williams also discusses the health information genome sequencing can and cannot uncover; incidental findings, or what happens when sequencing reveals unexpected health concerns; and the potentially dramatic impact of this transformative healthcare technology on the healthcare system.
Thomas R. Insel, MD
Rethinking Mental Illness
Dr. Insel, Director of the National Institute of Mental Health and former psychiatry professor at Emory University, explores the state of mental disorders in the United States and the role of genetics and other scientific advances in improving diagnosis and treatment methods, revolutionizing the field of psychiatry.
Glen R. Hanson, PhD, DDS
Drug Abuse: A Family Matter?
Researchers have determined that the prevalence of inheriting drug abuse ranges from 40 to 60 percent, suggesting that vulnerability to drug addiction is not merely environmental, but also genetic. Dr. Hanson, Professor of Pharmacology and Toxicology at the University of Utah and former director of the National Institute on Drug Abuse, explores the genetic elements of drug abuse.
Cynthia Kenyon, PhD
Genes from the Fountain of Youth
Aging is actively controlled by genes. All animals, and possibly humans too, seem to have the potential to live much longer than they normally do. Cynthia Kenyon, PhD, explores the mechanisms by which the rate of aging can be slowed down. Dr. Kenyon is Distinguished Professor of Biochemistry and Biophysics, American Cancer Society Research Professor and Director of the Hillblom Center for the Biology of Aging at the University of California, San Francisco.
Rick Kittles, PhD
Alice Dreger, PhD
Jeffrey Friedman, MD, PhD
The Biologic Basis of Obesity
Jeffrey Friedman, MD, PhD, Marilyn M. Simpson Professor and head of the Laboratory of Molecular Genetics at Rockefeller University, discusses what his team learned about the biological processes that regulate weight and appetite, and how further research could lead to a better understanding of obesity.
Juan Enriquez, PhD
From Reading to Writing Life Code
Juan Enriquez, PhD, Managing Director of Excel Venture Management and accomplished writer, businessman, and academic, explores what is possible using genome technology, and how it stands to revolutionize our lives.
George Church, PhD
Personal Genomes and Web 2.0 Volunteerism
Do genes help predict disease, help you decide on insurance, or help researchers discover your family traits? Can we work together to make a bio-weather map, tracking pathogens and allergens around the globe? Is a microscopic flake of skin from a crime scene enough to determine a name, a face, and a psychiatric profile? George Church, PhD, Professor of Genetics at Harvard Medical School, explores cutting-edge genomics research and technology.
Drew Endy, PhD
Building a New Biology
Drew Endy, PhD, Assistant Professor of Bioengineering, Stanford University, discusses powerful new technologies that allow life to be built from scratch. New engineered organisms are being constructed to help cure cancer, produce renewable energy, and assemble living computers. But who will control these new biotechnologies?
Sean Morrison, PhD
The Science and Politics of Stem Cells, Aging, and Cancer
Sean Morrison, PhD, discusses the basics of stem cells, the roles that stem cells play in cancer and aging, and the ways in which state and federal politics have impacted stem cell research. Dr. Morrison is Associate Professor, University of Michigan Medical School; Director, University of Michigan Center for Stem Cell Biology; Investigator, Howard Hughes Medical Institute.
Eugenie C. Scott
Robert T. Pennock
Evolution: The Impact of Social and Political Concerns on Science
Evolution is a complex and controversial subject with profound scientific, educational, and legal implications. Two experts provide different perspectives:
Eugenie C. Scott, Executive Director of the National Center for Science Education, addresses the political and social issues challenging the science classroom.
Robert T. Pennock, Professor of History, Philosophy, and Sociology of Science at Michigan State University, defines what science is and is not.
Rick Kittles, PhD
Race, Genetic Ancestry and Disease
Rick Kittles, PhD, Associate Professor of Molecular Virology, Immunology and Medical Genetics at the Ohio State University Medical Center, explains how DNA is used to trace African American ancestry and how genetics can affect complex traits and diseases such as prostate cancer, personality traits, and skin color.