Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Kyle P Eagen, PhD

Kyle P Eagen, PhD

Feinberg Fellow

Instructor of Biochemistry and Molecular Genetics



Searle Building Room 6-525
320 E Superior
Chicago IL 60611

Education/Research Website

Education and Certification

PhD: Stanford University, Biophysics (2017)


Description of Interests

The molecular basis of DNA folding within interphase nuclei and mitotic chromosomes is one of the great mysteries of biology and has fascinated scientists for over a century. An increasing number of human diseases, from congenital malformations to cancer, have been linked to DNA misfolding, hastening the need to resolve this mystery. We combine concepts and approaches from structural biology and biochemistry with methods and analytical tools from molecular biology and genomics to determine the structural and biochemical basis of chromatin folding and chromosome condensation. Our long-term goal is to contribute fundamental knowledge about the nature of DNA folding and elucidate general principles of chromatin and chromosome organization that will enable insights into human disease processes and serve as a basis for developing targeted, precise therapeutics.

Interests (Keywords)

Biochemistry: Nucleic Acid; Cell Biology; Chromatin; Epigenetics; Genomics; Molecular Biology; Nuclear Structure and Developmental Biology; Nucleic Acid Structure/Function

Research and Publications


Institutes and Centers

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