Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Focus of Work

Bio

The primary research focus of the lab is to understand aberrant transcriptional and epigenetic regulation of prostate cancer. We utilize high-throughput genomic techniques in combination with bioinformatics/statistical analysis to generate hypothetical concepts. We then test these hypotheses using traditional molecular or cellular biological approaches and examine the functional relevance of innovative mechanisms using in vitro cell line and in vivo mouse models. Transcription factors of part...[Read full text]The primary research focus of the lab is to understand aberrant transcriptional and epigenetic regulation of prostate cancer. We utilize high-throughput genomic techniques in combination with bioinformatics/statistical analysis to generate hypothetical concepts. We then test these hypotheses using traditional molecular or cellular biological approaches and examine the functional relevance of innovative mechanisms using in vitro cell line and in vivo mouse models. Transcription factors of particular interest to us include androgen receptor (AR), FoxA1, Polycomb group protein (EZH2), and the Ets family protein (ERG). Based on the genetics and epigenetics of the disease, we also pursue translational research to define diagnostic / prognostic biomarkers and to pursue novel therapeutics strategies for treating advanced prostate cancer.[Shorten text]

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Education and Certification

  • MD: Peking University (1998)
  • PhD: University of Michigan (2004)

Contact

Administrative office: 312-503-1761

Robert H Lurie Medical Research Center Room 5-117
303 E Superior
Chicago IL 60611