Focus of Work
Another focus of research in Zhang lab is to identify immune components that control breast cancer metastasis. Chronic inflammation not only increases neoplastic transformation but also drives the inhibition of the immune response in a protective negative-feedback mechanism. Suppressive immune cells are recruited to the sites of inflammation and function to inhibit both innate and adaptive immune responses, enabling tumor tolerance and unmitigated tumor progression. To study the interplay between tumor and immune cells, Zhang lab has developed a unique animal model of breast cancer that reproduces different stages of breast cancer bone metastasis. Molecules that control tumor-immune cell interaction and immunosuppression have been identified. We are currently studying roles of these genes in tumor-driven evolution that control chronic inflammation and immunosuppression.[Shorten text]
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Education and Certification
- PhD: State University of New York (1992)
- Postdoctoral Fellowship: Duke University (1993)
- Postdoctoral Fellowship: Harvard Medical School (1997)
Robert H Lurie Medical Research Center Room 6-107
303 E Superior
Chicago IL 60611
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