Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Richard M Longnecker, PhD

Richard M Longnecker, PhD

Dan and Bertha Spear Research Professor

Professor of Microbiology-Immunology

Contact

312-503-0467

Ward Building Room 6-245
303 E Chicago Avenue
Chicago IL 60611

r-longnecker( at )northwestern.edu

Education/Research Website

Education and Certification

PhD: University of Chicago, Virology (1987)
Postdoctoral Fellowship: University of Chicago (1988)
Postdoctoral Fellowship: Harvard University (1992)

Interests

Description of Interests

Research in the Longnecker laboratory focuses on herpes simplex virus (HSV) and Epstein-Barr virus (EBV). These viruses typically cause self-limiting disease within the human population but both can be associated with serious complications. EBV is associated with variety of hematopoietic cancers such as African Burkitt lymphoma, Hodgkin Lymphoma and adult T-cell leukemia. EBV-associated lymphoproliferative disease occurs in individuals with congenital or acquired cellular immune deficiencies. The two notable epithelial diseases associated with EBV infection are nasopharyngeal cancer and oral hairy leukoplakia. Similar to EBV, HSV latent infections are very common in humans. HSV typically does not cause severe disease but is associated with localized mucocutaneous lesions, but in some cases can cause meningitis and encephalitis. The Longnecker laboratory focuses on several aspects of EBV and HSV replication and pathogenesis. First, the molecular basis EBV transformation and how it relates to cancer is being investigated. The laboratory is currently screening selective inhibitors that may be beneficial in EBV-associated cancers such as Hodgkin lymphoma, Burkitt lymphoma and proliferative disorders that occur in HIV/AIDS and transplant patients. Second, the laboratory is investigating herpesvirus latency in the human host and pathogenesis associated with infections in humans. In this regard, the laboratory is developing animal models for EBV and HSV infections. Finally, the laboratory is investigating the function of herpesvirus encoded proteins and the cellular receptors that are important for infection both using in vivo culture models as well as animal models. Ultimately, studies by the Longnecker laboratory may provide insight for the development of novel therapeutics for the treatment of herpesvirus infections in humans and better understanding of the herpesvirus life cycle in the human host.

Interests (Keywords)

Cancer Biology; Signal Transduction; Systems Biology; Viral Oncology; Viral Pathogenesis; Virology

Research and Publications

Northwestern Scholars

View the Richard M Longnecker Northwestern Scholars profile.

Northwestern Scholars is a searchable database including faculty profiles, publications, and grant data from across all Northwestern University disciplines. It connects faculty members from all disciplines across Northwestern University to new research opportunities and collaborations at Northwestern.

 

Institutes and Centers

Disclosures

 

Edit My Profile

Northwestern medical faculty can update their faculty profile any time and as often as they like using the web-based, secure platform. It is the responsibility of faculty members to add content and build a profile that reflects their contributions to Feinberg and their specialty.