Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Kathleen J Green, PhD

Kathleen J Green, PhD

Joseph L. Mayberry, Sr., Professor of Pathology and Toxicology

Professor of Pathology and Dermatology

Focus of Work

Bio

intercellular junctions, adhesion, desmosomes, adherens junctions, signal transduction, cell motility, skin disease, cadherins, cancer metastasis<br><br>

Our laboratory is interested in the function and regulation of intercellular
junction molecules in desmosomes and adherens junctions that act to mediate cell-cell adhesion and attachment of the cytoskeleton to the cell surface. Defects in junctional components caused by mutation or post-translational modification result in a variety of patholo...[Read full text]
intercellular junctions, adhesion, desmosomes, adherens junctions, signal transduction, cell motility, skin disease, cadherins, cancer metastasis<br><br>

Our laboratory is interested in the function and regulation of intercellular
junction molecules in desmosomes and adherens junctions that act to mediate cell-cell adhesion and attachment of the cytoskeleton to the cell surface. Defects in junctional components caused by mutation or post-translational modification result in a variety of pathologies ranging from skin and cardiac disease to cancer. In addition, junction-associated molecules are involved in non-junctional functions such as signaling in development and differentiation. The lab uses a multi-faceted approach to dissect the function of cadherins, armadillo and plakin family junction components including but not limited to collaborative atomic structure determinations, molecular genetics, live cell imaging and trangenic mouse approaches.[Shorten text]

Keywords

Select a keyword to see all related Feinberg faculty via the main faculty profile site.


Education and Certification

  • PhD: Washington University, Cell & Developmental Biology (1982)

Northwestern Scholars

View the Kathleen J Green Northwestern Scholars profile.

Northwestern Scholars is a searchable database of research expertise across all disciplines at Northwestern University. You can view collaboration networks among researchers within Northwestern and with external scholars.