Northwestern University Feinberg School of Medicine

Center for Genetic Medicine

Whole Genome Genotyping

High density SNP analysis can be used to perform linkage analysis, association studies, LOH and copy number studies. The Core principally processes genotyping arrays available from Illumina.

Illumina Infinium HD BeadChips — Omni and Core Families

Illumina Infinium HD BeadChips Omni and Core beadchip families can analyze from 250,000 to 5,000,000 SNPs per sample. Infinium HD process technology uses hybridization of fragmented genomic DNA combined with single-base extension staining to reliably and accurately call SNP identities. For custom mid- to high-density genotyping, the newest chip— iSelect Infinium Genotyping Beadchip—can include 3,000-1,000,000 SNPs of interest across 24 or 4 samples, respectively. All Illumina staining and extension setups are automated using the Tecan Freedom EVO system.