Transgenic and Targeted Mutagenesis Core
The Northwestern University Transgenic and Targeted Mutagenesis Laboratory (TTML) is a shared resource designed to produce genetically engineered mice for research projects of investigators on the Evanston campus, in the Feinberg School of Medicine, the Robert H. Lurie Comprehensive Cancer Center, and the Children's Hospital of Chicago Research Center.
Our laboratory provides a broad, comprehensive range of services to NU investigators, including generation of transgenic mice, gene targeting of embryonic stem (ES) cells, ES cell microinjection into blastocysts to create germline competent chimera, cryopreservation and long-term storage of mouse sperm/embryos, recovery of mouse lines from cryopreserved germplasm, in vitro fertilization (for mouse line rescue), and rederivation of pathogen free mouse strains.
The Transgenic and Targeted Mutagenesis Laboratory is sponsored by:
The Center for Genetic Medicine
The Robert H. Lurie Comprehensive Cancer Center
